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2009| January-June | Volume 1 | Issue 1
Online since
June 6, 2009
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REVIEW ARTICLES
Oxidative stress in ageing of hair
Ralph M Trueb
January-June 2009, 1(1):6-14
DOI
:10.4103/0974-7753.51923
PMID
:20805969
Experimental evidence supports the hypothesis that oxidative stress plays a major role in the ageing process. Reactive oxygen species are generated by a multitude of endogenous and environmental challenges. Reactive oxygen species or free radicals are highly reactive molecules that can directly damage cellular structural membranes, lipids, proteins, and DNA. The body possesses endogenous defence mechanisms, such as antioxidative enzymes and non-enzymatic antioxidative molecules, protecting it from free radicals by reducing and neutralizing them. With age, the production of free radicals increases, while the endogenous defence mechanisms decrease. This imbalance leads to the progressive damage of cellular structures, presumably resulting in the ageing phenotype. Ageing of hair manifests as decrease of melanocyte function or graying, and decrease in hair production or alopecia. There is circumstantial evidence that oxidative stress may be a pivotal mechanism contributing to hair graying and hair loss. New insights into the role and prevention of oxidative stress could open new strategies for intervention and reversal of the hair graying process and age-dependent alopecia.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
19,087
668
44
BRIEF COMMUNICATION
Finasteride induced gynecomastia: Case report and review of the literature
Yuval Ramot, Tali Czarnowicki, Abraham Zlotogorski
January-June 2009, 1(1):27-29
DOI
:10.4103/0974-7753.51930
PMID
:20805972
Finasteride (1 mg/day) is widely utilized by dermatologists for the treatment of androgenetic alopecia. Although enjoying a relatively good safety profile, several sex-related adverse effects have been reported with this drug. Here we report two cases of gynecomastia, one of them bilateral, caused by Propecia
®
prescribed for the treatment of androgenetic alopecia. Although relatively rare, physicians should be aware of this side effect and inform their patients when prescribing this medication.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
9,334
261
18
COMMENTARY
Tonsuring: Myths and facts
Kaliaperumal Karthikeyan
January-June 2009, 1(1):33-34
DOI
:10.4103/0974-7753.51927
PMID
:20805974
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
6,256
192
4
ORIGINAL ARTICLE
Dealing wildlife offences in India: Role of the hair as physical evidence
Vivek Sahajpal, SP Goyal, Kumudbala Singh, Vinod Thakur
January-June 2009, 1(1):18-26
DOI
:10.4103/0974-7753.51928
PMID
:20805971
India is known for its rich biodiversity, with a wide variety of wild floral and faunal species. This wildlife treasure of ours faces the threat of extinction due to rampant poaching and illegal trade. With most of the wildlife offence cases related to mammals having hair as physical evidence, it becomes imperative to use this evidence in the best possible way for wildlife crime investigation. We discuss the value of hair evidence with special reference to species characterization/identification using microscopic hair characteristics, keratin patterns, and mitochondrial DNA typing. The relevance of the techniques with respect to Indian scenario is specially taken care of and microscopic hair characteristics of one of the highly endangered species along with its keratin pattern are described. Finally, the use of mitochondrial DNA for species identification is also discussed.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
5,310
327
4
CASE REPORT
Neurodegenerative disorders with hair abnormalities: An emergency room consultation for dermatologists
Arun C Inamadar, Aparna Palit
January-June 2009, 1(1):30-32
DOI
:10.4103/0974-7753.51929
PMID
:20805973
Menke's syndrome and Elejalde disease are the two neurodegenerative disorders of dermatological interest. These patients present with characteristic hair changes which may be of diagnostic value in resource-poor setup where facilities for specific genetic analysis are not available. Simple light microscopic examination of hair may be a helpful diagnostic tool to pick up such cases.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
3,991
120
2
REVIEW ARTICLES
Hair abnormalities in genetic disorders of junctions
Paul D Yesudian
January-June 2009, 1(1):15-17
DOI
:10.4103/0974-7753.51926
PMID
:20805970
The desmosomes form the basis of intercellular support structure within the epidermis. However, various junctions, including gap junctions, adherens junctions, and tight junctions play an important part in the intercellular bridges that are vital for cell-cell interactions and structural stability.
Numerous mutations can affect the genetic structure that make up these junctions and in turn cause disease. Most of these conditions have hair abnormalities and this article will briefly elucidate the various manifestations in the hair. As these junctional elements are found in other organs like the heart, liver, and eye, there could be serious systemic associations along with the hair changes.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
3,461
196
2
REMINISCENCE
Journey through the world of hair
Sundaram Murugusundram
January-June 2009, 1(1):3-3
DOI
:10.4103/0974-7753.51918
PMID
:20805967
[FULL TEXT]
[PDF]
[PubMed]
2,610
211
-
COMMENTARY
Some thoughts: Scattered hair and there!
Shyam B Verma
January-June 2009, 1(1):4-5
DOI
:10.4103/0974-7753.51921
PMID
:20805968
[FULL TEXT]
[PDF]
[PubMed]
2,635
127
-
EDITORIAL
Why another journal?
Patrick Yesudian
January-June 2009, 1(1):1-1
DOI
:10.4103/0974-7753.51913
PMID
:20805965
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
2,520
162
2
GUEST EDITORIAL
Twenty years of European hair research society
Ralph M Trueb
January-June 2009, 1(1):2-2
DOI
:10.4103/0974-7753.51916
PMID
:20805966
[FULL TEXT]
[PDF]
[PubMed]
2,473
171
-
CLINICAL CHALLENGE
Spangled hair in siblings
Sundaram Murugusundram
January-June 2009, 1(1):35-36
DOI
:10.4103/0974-7753.51925
PMID
:20805975
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
2,435
106
2
EHRS 2009
Guest editorial - Fourteenth European hair research society annual meeting 2009, Graz, Austria
Daisy Kopera
January-June 2009, 1(1):39-39
[FULL TEXT]
[PDF]
2,135
75
-
John Ebling lecture
January-June 2009, 1(1):44-44
[FULL TEXT]
[PDF]
1,514
69
-
Oral presentations
January-June 2009, 1(1):45-59
[FULL TEXT]
[PDF]
1,413
130
-
Posters
January-June 2009, 1(1):60-74
[FULL TEXT]
[PDF]
1,396
134
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Opening lecture
January-June 2009, 1(1):42-42
[FULL TEXT]
[PDF]
1,429
72
-
Tricho-philosophical morning dew
January-June 2009, 1(1):43-43
[FULL TEXT]
[PDF]
1,386
64
-
EHRS 2009 program
January-June 2009, 1(1):40-41
[FULL TEXT]
[PDF]
1,335
89
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Online since 10
th
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