International Journal of Trichology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 11  |  Issue : 4  |  Page : 153--158

Evaluation of physiological, psychological, and lifestyle factors associated with premature hair graying


Katherine G Thompson, Mark C Marchitto, Bao Chau K. Ly, Anna L Chien 
 Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Correspondence Address:
Dr Anna L Chien
Department of Dermatology, Johns Hopkins University School of Medicine, 601 N. Caroline St., Suite 8033, Baltimore, MD 21287
USA

Background: Canities, or hair graying, is believed to be driven by the cytotoxic effect of reactive oxygen species on follicular melanocytes, thus raising the concern that premature hair graying (PHG) may represent an outward sign of systemic oxidative stress.Objective: This study aimed to identify the physiological, psychological, and lifestyle factors associated with PHG (defined as graying at age ≤30 years) in men and women. Materials and Methods: Data from 467 participants (female = 354 and male = 113; age: 18–77 years) were collected and analyzed, including demographic information, medical history, family history, supplement intake, and lifestyle factors. Results: PHG was found to be significantly associated with a history of PHG in the mother, P<0.001, odds ratio (OR) = 3.165; father, P<0.001, OR = 5.166; maternal grandparent, P= 0.002, OR = 2.442; paternal grandparent, P= 0.007, OR = 2.369; and siblings, P<0.001, OR = 3.125. PHG was significantly associated with iron deficiency (P = 0.026, OR = 1.751) and family history of depression (P = 0.012, OR = 1.603), while herpes simplex virus infection (P = 0.004, OR = 0.367) and smoking history (P = 0.003) demonstrated significant negative associations. In Caucasians only (n = 306), in addition to these trends, irritable bowel syndrome was also significantly associated with PHG (P = 0.010, OR = 2.753). In Asians only (n = 75), history of heart disease in a first-degree relative (P = 0.038) was significantly associated with PHG. Limitations: As a survey study, the findings may be subject to recall bias. Conclusions: Important associations exist between PHG and family history of PHG, psychiatric history, supplement use, and vitamin deficiencies, providing insight into the pathophysiology and potential comorbidities of PHG.


How to cite this article:
Thompson KG, Marchitto MC, Ly BC, Chien AL. Evaluation of physiological, psychological, and lifestyle factors associated with premature hair graying.Int J Trichol 2019;11:153-158


How to cite this URL:
Thompson KG, Marchitto MC, Ly BC, Chien AL. Evaluation of physiological, psychological, and lifestyle factors associated with premature hair graying. Int J Trichol [serial online] 2019 [cited 2020 Dec 5 ];11:153-158
Available from: https://www.ijtrichology.com/article.asp?issn=0974-7753;year=2019;volume=11;issue=4;spage=153;epage=158;aulast=Thompson;type=0