|LETTER TO EDITOR
|Year : 2022 | Volume
| Issue : 5 | Page : 186-187
Family history of autoimmunity and endocrine disorders in patients with alopecia areata. A Greek study
Department of Dermatology, Thriassio General Hospital, Athens, Greece
|Date of Submission||10-Dec-2021|
|Date of Acceptance||14-Jun-2022|
|Date of Web Publication||7-Oct-2022|
Department of Dermatology, Thriassio General Hospital, Avenue Gennimata, Po. 19200, Magula, Athens
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Klimi E. Family history of autoimmunity and endocrine disorders in patients with alopecia areata. A Greek study. Int J Trichol 2022;14:186-7
Alopecia areata is a nonscarring hair loss of autoimmune origin affecting 2% of the general population. Several studies have detected autoimmune disorders in the family history of patients with alopecia areata. This study aims to find the prevalence of autoimmune and endocrine disorders in the family history of males and female patients with alopecia areata and to compare it with the prevalence of these disorders in the general population. Patients above 18 years of age were included in the study.Family history was taken by the consulting physician at the time of the first consultation by completing a prepared questionnaire. Thirty-three males and thirty-one females were diagnosed with alopecia areata, all presented patchy alopecia. The prevalence of alopecia areata in the family members of females was 16.12%, (5 cases), 12.12% for the males (4 cases), which is statistically significant higher than this of the general population-2.1% P < 0.0001 in both groups [Table 1]. The prevalence of psoriasis in the family members of females is 6.45% (2 cases) and of the males 6.6% (2.cases), which is statistically significant greater than this of the general population-2%, P < 0.021, P < 0.017, respectively, [Table 1]. The prevalence of hypothyroidism it was not possible from the collected data to determine whether it was of autoimmune origin or not is 9.6% (3 cases), in the family members of females not statistically significant P < 0.111 and in the males 15.15% (5 cases) statistically significant higher than this of the general population-5%. The prevalence of rheumatoid arthritis was 12.9% (4 cases), in the family members of females, 3.63% (1 case), for males which is statistically significant higher than this of the general population-0.68% – P < 0001, P < 0.015, respectively. The prevalence of atopic eczema in the family members of females is 12.9% (4 cases) and of males 9.10% (3 cases), was not statistically significant higher than this of the general population-10.2, P < 0.492, P < 0777, respectively. As shown in [Table 1], the prevalence of diabetes insulin dependent - no cases reported - was not statistically significant higher than this of the general population - 0.24% in both groups. As shown in [Table 1], limitation is the small number of the patients in this study. However, it demonstrates that the prevalence of atopic eczema and of diabetes insulin dependent regardless of gender was not statistically significant different from this in the general population. It also reveals regardless of gender statistically significant increased prevalence of alopecia areata, psoriasis, and rheumatoid arthritis in the family members of patients with alopecia areata, suggesting a common immunopathogenic mechanism linked to the pathogenesis of these three disorders. Family history should be taken with caution by the examining physician to detect autoimmunity in the family history of patients with alopecia areata. In addition, larger studies are needed to investigate the impact of parental autoimmunity to the development of alopecia areata in the offspring.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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