International Journal of Trichology International Journal of Trichology
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Year : 2022  |  Volume : 14  |  Issue : 2  |  Page : 49-54

Targeted nutritional supplementation for telogen effluvium: Multicenter study on efficacy of a hydrolyzed collagen, vitamin., and mineral-based induction and maintenance treatment

1 R&D Department, Laboratorio Genové, Sant Llorenç d'Hortons, Spain
2 Department of Dermatology, Centro Médico Teknon, Barcelona, Spain
3 Department of Dermatology, Hospital Universitario Virgen de las Nieves, Granada, Spain
4 Centre for Dermatology and Hair Diseases Professor Trüeb, Zurich-Wallisellen, Switzerland

Correspondence Address:
Ralph Michel Trüeb
Center for Dermatology and Hair Diseases Professor Trüeb, Bahnhofplatz 1A, CH-8304 Wallisellen
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijt.ijt_57_21

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Background: The condition of the hair is closely related to the nutritional state. Normal supply, uptake, and transport of nutrients are of fundamental importance in tissues with a high biosynthetic activity such as the hair follicle. Objective: The objective of the study was to evaluate the efficacy of a nutritional-based induction and maintenance treatment for telogen effluvium formulated with a combination of hydrolyzed collagen, amino acids, vitamins, and minerals. Patients and Methods: The clinical studies were conducted with each nutritional treatment individually, and both in sequential combination. Anagen/telogen ratio, hair density, and tolerability of treatment were assessed at baseline, 4 weeks of induction therapy, and another 12 weeks of maintenance treatment. Trichogram results showed a significant improvement of the anagen/telogen ratio between baseline and final visit at 16 weeks, with an increase of hair in anagen and a reduction of hair in telogen. Furthermore, a significant increase was observed in hair density. The effect size of the combination treatment was higher than that of each of the two products used separately as monotherapy. Conclusions: The study results provide a proof of concept for targeted nutritional supplementation for the treatment of telogen effluvium, with a special emphasis on the role of collagen, besides specific amino acids, vitamins, and minerals.

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