International Journal of Trichology International Journal of Trichology
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CASE REPORT
Year : 2020  |  Volume : 12  |  Issue : 4  |  Page : 188-190

Clinical experience with oral tofacitinib in a patient with alopecia areata universalis and rheumatoid arthritis


Department of Dermatology, Federal University of Paraná, Curitiba, Paraná, Brazil

Correspondence Address:
Dr. Daniele Tiemi Abe
Rua General Carneiro, 181 - Alto da Gloria, Curitiba, Parana
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijt.ijt_107_20

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Alopecia areata (AA) is a chronic and autoimmune disease frequently characterized by a challenge management between dermatologists. At present, JAK-inhibitors have demonstrated encouraging results in AA treatment. Therefore, this study reports a case of alopecia universalis in a patient with rheumatoid arthritis (RA), whose methotrexate therapy shown unsatisfactory response in RA control. After the introduction of 10 mg (oral route) per day of tofacitinib, a JAK-inhibitor, an improvement of almost 50% in severity alopecia tool score occurred with maintained response even after 3 months of medication suspension. From this time, we corroborate the effectiveness of JAK-inhibitors presented in the scientific literature. In addition, we inquiry the real impact of methotrexate on JAK-start signaling inhibition in AA pathophysiology.


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