Development of pityriasis amiantacea after valproic acid therapy

Julio A Diaz-Perez; Joel C Joyce; Thomas L Cibull; Thomas A Victor

doi:10.4103/ijt.ijt_53_18

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CASE REPORT

Year : 2018 | Volume : 10 | Issue : 5 | Page : 237-239

Development of pityriasis amiantacea after valproic acid therapy

Julio A Diaz-Perez¹, Joel C Joyce², Thomas L Cibull³, Thomas A Victor³
¹ Department of Pathology, Northshore University Health System, University of Chicago, Chicago, IL; Department of Pathology, Jackson Health System, University of Miami, Miami, FL, USA
² Division of Dermatology, Northshore University Health System, University of Chicago, Chicago, IL, USA
³ Department of Pathology, Northshore University Health System, University of Chicago, Chicago, IL, USA

Correspondence Address:
Julio A Diaz-Perez
Department of Pathology, Jackson Health System, University of Miami, Miami, FL
USA

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/ijt.ijt_53_18

Here, we present the case of a 16-year-old male who developed pityriasis amiantacea (PA) after the use of valproic acid. We propose that the keratinocyte proliferative activity of valproic acid mediated through the inhibition of glycogen synthase kinase-3β, and subsequent activation of the Wnt/β-catenin pathway could play a role in the development of PA. We additionally review the most relevant characteristics of this disease.

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