International Journal of Trichology International Journal of Trichology
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   2013| April-June  | Volume 5 | Issue 2  
    Online since December 12, 2013

 
 
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REVIEW ARTICLE
Canities subita: A reappraisal of evidence based on 196 case reports published in the medical literature
Michael Nahm, Alexander A Navarini, Emily Williams Kelly
April-June 2013, 5(2):63-68
DOI:10.4103/0974-7753.122959  PMID:24403766
We have reviewed the medical literature on unusually rapid Canities of body hair to assess whether the reported clinical evidence can be explained with the current hypotheses of pathogenetic mechanisms. We screened the medical literature from 1800 onward, searching for as many case reports as possible. We assessed literature in Dutch, English, French, German, Italian and Spanish and included all cases, which contained an explicit mention or description of unusually rapid graying or whitening of hair. Case reports were classified into three categories: Cases are "authenticated" when the authors personally observed the rapid color change, "non-authenticated" when they saw the subject only after the alleged color change and "anecdotal" when authors were told about the case by a third party. In total, we found 196 cases of which 44 were authenticated. These studies reported the graying of human hair in the context of aging, somatic diseases, emotional trauma or stress and psychiatric disorders. Numerous cases involved not only scalp hair, but also beards, eyelashes and other body hair. Several authors stressed that there was no alopecia. Although plausible explanations exist to explain Canities subita occurring together with an effluvium, the observation of viable hair losing color along the axis within a timespan shorter than its growth rate remain as yet unexplained.
  4,614 62 -
ORIGINAL ARTICLES
Hormonal profile in Indian men with premature androgenetic alopecia
Smita Narad, Sushil Pande, Madhur Gupta, Suresh Chari
April-June 2013, 5(2):69-72
DOI:10.4103/0974-7753.122961  PMID:24403767
Introduction: Alopecia in male is considered as a genetically determined disorder characterized by increased level of local androgen metabolite and increase androgen receptor binding in balding areas. Frequent deviations of hormones from normal values have been reported in men diagnosed with premature androgenetic alopecia (AGA) especially for androgens, gonadotropins and sex hormone binding globulin (SHBG). Different studies in the past have inferred that premature baldness before the age of thirty in males could be considered equivalent to the polycystic ovary syndrome (PCOS) in female. Materials and Methods: Hormonal profile of 50 men with severe premature balding before 30 years of age were compared with same numbers of age matched controls. The serum concentrations of total testosterone, dehydroepiandrosterone sulfate, luteinizing hormone, follicle stimulating hormone, SHBG, insulin and fasting blood sugar were estimated. Statistical analysis was performed with paired Student's t-test for cases and controls. Results: Decreased levels of SHBG with high free androgen index were found in cases when compared with the controls. Conclusion: Though altered hormonal profile may coexist in some of men with premature AGA it can't be considered as male equivalent to PCOS in female or the metabolic syndrome.
  3,034 149 -
Evaluation of perifollicular inflammation of donor area during hair transplantation in androgenetic alopecia and its comparison with controls
Balakrishnan Nirmal, Savitha Somiah, Sarvajnamurthy A Sacchidanand, Dayananda S Biligi, Seetu Palo
April-June 2013, 5(2):73-76
DOI:10.4103/0974-7753.122963  PMID:24403768
Background: Mild perifollicular inflammation is seen in both androgenetic alopecia (AGA) cases and normal controls, whereas moderate or dense inflammation with concentric layers of collagen, is seen in AGA cases but only in very few normal controls, and may lessen the response to topical minoxidil. Moderate or dense lymphocytic inflammation and perifollicular fibrosis have poor hair growth following transplantation. Aim: The purpose of the study is to evaluate the perifollicular lymphocytic inflammation and fibrosis in AGA patients during follicular unit hair transplantation (FUT) and its comparison in normal controls. Materials and Methods: A total of 21 male patients with AGA and 7 matched controls participated in the study. Histopathological analysis of biopsy specimens from donor strip of patients during the hair transplantation and two 4 mm punch biopsies on controls were performed. Morphometric analysis was performed and perifollicular fibrosis was scored based on the width of the condensed collagen at the lower infundibulum and isthmus from 0 to 3. Perifollicular infiltrate was also scored 0-3 and a total score of 3 or more out of 6 was considered significant. Results: Nearly 76% of AGA patients had perifollicular fibrosis more than 50 μm at ×200 magnification. Almost 33.33% patients had moderate/dense perifollicular lymphocytic infiltrate whereas none of the controls had it. Total score in AGA cases was significantly higher than controls (P = 0.012) using Chi-square test. Out of 21 patients, 13 had a score of 3 or more and were followed-up with monthly treatment with intralesional steroids using a dermaroller. Conclusion: Histopathological evaluation of the donor area is a must during hair transplantation to evaluate the extent of perifollicular inflammation and achieve better results by following it up with treatment directed to decrease the inflammation.
  2,984 78 1
CASE REPORTS
A case of neurodermatitis circumscipta of scalp presenting as patchy alopecia
H Ambika, C Sujatha Vinod, J Sushmita
April-June 2013, 5(2):94-96
DOI:10.4103/0974-7753.122971  PMID:24403775
Neurodermatitis or Lichen simplex chronicus (LSC) is chronic skin disease in which emotional factors have a key role in the initiation of disease. A sixty year old lady presented with itcy lesion of scalp with localised area of loss of hair. After proper history taking and investigations she was diagnosed as LSC of scalp. She was treated with intralesional steroids,oral doxepin and psychotherapy. Complete remission of symptoms with total regrowth of hair occured in 3 months.The key role of emotional factors in causation of LSC and a proper psychotherapy along with dermatological treatment is necessary for complete cure of this condition.
  2,418 38 -
Severe onycholysis in a card illusionist with alopecia areata universalis
Antonella Tosti, Massimiliano Pazzaglia, Michela Venturi, Nilton Di Chiacchio
April-June 2013, 5(2):81-82
DOI:10.4103/0974-7753.122966  PMID:24403770
In patients with alopecia areata (AA), nail abnormalities due to nail matrix inflammation are common and usually not severe. We report the case of a 23-year-old man with AA universalis, who developed severe abnormalities of all his fingernails. Systemic steroids improved the onycholysis that had an important impact on the patient's job, as he was a card illusionist.
  2,417 23 -
BRIEF COMMUNICATION
Stem cell niche is partially lost during follicular plucking: A preliminary pilot study
Anil Kumar, Somesh Gupta, Sujata Mohanty, Balram Bhargava, Balram Airan
April-June 2013, 5(2):97-100
DOI:10.4103/0974-7753.122973  PMID:24403776
Background: Clinical hair transplant studies have revealed that follicular unit extraction (FUE) is superior in terms of stable hair growth in comparison to follicular plucking (FP). Various reasons have been cited for this clinical outcome. FUE and FP are employed to obtain the hair follicle units for hair transplant and recently for cell based therapies in vitiligo. However, there is no scientific data available on the comparison of stem cell fraction in the cell suspension obtained by FUE and FP. Therefore, we undertook this study to compare the percentage of stem cells in the hair follicle obtained by FUE and FP. Objective: The purpose of the following study is to evaluate the quantitative stem cell pool in the hair follicle obtained by FUE and FP. Materials and Methods: A total of 3 human subjects were enrolled with age groups of 17-25 years. Both methods of tissue harvest: FUE and FP; were employed on each subject. There was no vitiligo lesion on the scalp in any of the patients. Hair follicles were incubated with trypsin-EDTA solution at 37°C for 90 min to separate outer root sheath cells. The cell suspension was passed through a 70 μm cell strainer; filtrate was centrifuged to obtain the cell pellet. Cells were labeled with cluster of differentiation (CD200) antibody and acquired with flowcytometry. Results: The mean percentage of CD200 positive cells in FUE and FP method come out to be 8.43 and 1.63 respectively (P = 0.0152). Conclusion: FUE is a better method of the hair follicle harvesting for cell based applications as the stem cell fraction is significantly higher in comparison to FP.
  2,042 70 1
LETTERS TO EDITOR
Unusual case of hypertrichosis
Rajeev Philip, Saran Sanjay, Gutch Manish, Gupta Keshavkumar
April-June 2013, 5(2):104-106
DOI:10.4103/0974-7753.122977  PMID:24403780
  2,060 35 -
Tuft of hair at an unusual location
KVS Hari Kumar, AK Gupta
April-June 2013, 5(2):103-104
DOI:10.4103/0974-7753.122976  PMID:24403779
  1,872 28 -
CASE REPORTS
Annular alopecia areata: Report of two cases
Manish Bansal, Kajal Manchanda, SS Pandey
April-June 2013, 5(2):91-93
DOI:10.4103/0974-7753.122970  PMID:24403774
Alopecia areata (AA) is an auto-immune disorder characterized by the appearance of non-scarring bald patches affecting the hair bearing areas of the body. Scalp is the most common site of involvement. AA can affect any age group. The usual pattern of the hair loss is oval or round. We hereby, report two cases of annular and circinate pattern of AA due to its unusual morphology.
  1,727 51 -
Cylindroma of the breast: A rare case report
Roopak Aggarwal, Oneal Gupta, Yogesh Kumar Yadav, Shruti Dogra
April-June 2013, 5(2):83-85
DOI:10.4103/0974-7753.122967  PMID:24403771
Cylindroma is a benign adnexal tumor, which occurs as solitary dermal nodules on the scalp and forehead. Cylindroma of the breast is a rare lesion. Fine-needle aspiration is often the first line of investigation. In this communication, we illustrate the cytomorphological feature of cylindroma in a 61-year-old female patient who presented with a breast lump. Fine-needle aspiration cytology in this case reveals the islands of tumor cells formed a "jig-saw" pattern, along with the bland, basaloid cells associated with globular, extracellular material. These features are typical of cylindroma, but differential diagnosis of adenoidcystic carcinoma should always be kept in mind as the management of both tumors are different.
  1,609 30 -
ORIGINAL ARTICLES
Evaluation of the degree of knee joint osteoarthritis in patients with early gray hair
Behrooz Kazemi, Alireza Ashraf, Mohammad Reza Namazi, Fariba Zarei, Shima Foruzi
April-June 2013, 5(2):77-80
DOI:10.4103/0974-7753.122964  PMID:24403769
Background: Osteoarthritis (OA) is the most common form of arthritis and one of the causes of pain and disability. The hair graying characteristic correlates strictly with chronological aging and take places to varying degrees in all individuals, disregarding gender or race. Aims: Comparison of the degrees of clinical and radiologic severity of the knee OA in individuals with early hair graying compared to ordinary individuals. Materials and Methods: A total of 60 patients with knee OA and similar demographic characteristics were enrolled in this study. All patients were classified in to 3 age subgroups in each of the case and control groups (30-40 year, 41-50 year, 51-60 year). In the case group, the patients must had early hair graying, too. Knee OA were classified using the Kellgren-Lawrence (KL) grading scale. Western Ontario McMaster University Osteoarthritis index (WOMAC) was applied to assess clinical severity of the knee OA. Results: The mean ± SD of WOMAC index in the case group was 60.7 ± 15.9 and in the control group was 55.3 ± 15.3 (P = 0.1). The mean rank of KL scale in case group was 35.3 and in the control group was 25.6 (P = 0.02). Conclusion: Even at the same age of OA onset, the rate of progression of radiological findings and the grade of joint destruction in individuals with early hair graying are greater than normal individuals. However, clinical and functional relevant remain unclear.
  1,498 43 -
CASE REPORTS
Isolated collagenoma on the scalp: A rare presentation
Surendra Kumar, Satyendra Kumar Singh, Alka Bansal, Manish Bansal
April-June 2013, 5(2):88-90
DOI:10.4103/0974-7753.122969  PMID:24403773
Connective tissue nevi of the skin are benign hamartomatous lesions consisting predominantly of one of the components of the extracellular matrix comprising of collagen, elastin or glycosaminoglycans type. Connective tissue nevi may be solitary or multiple, sporadic or inherited. Collagenomas are asymptomatic and usually occurs over upper trunk, arms, back, thighs and soles. We, hereby report a young boy with collagenoma over the scalp, a rare site.
  1,423 32 -
Familial trichotillomania in three generations
Yuval Ramot, Alexander Maly, Liran Horev, Abraham Zlotogorski
April-June 2013, 5(2):86-87
DOI:10.4103/0974-7753.122968  PMID:24403772
Trichotillomania (TTM) is a type of impulse control disorder, characterized by recurrent pulling of hair. The etiology of TTM is complex, but a genetic contribution to this condition was advocated based on a limited number of reports on familial TTM. We report a 13-year-old male with history of focal hair loss in the scalp. Examination showed a patchy area of hair loss, with several short broken hairs of varying lengths. Dermoscopy and pathology examinations were consistent with TTM. Upon further questioning, his father admitted repeated pulling of his beard. The paternal grandfather also suffers from severe hair pulling of his beard since puberty. To our knowledge, this is the first report of TTM in a 3 generation family. This report strengthens the possibility that TTM is a genetic disease, probably with a complex inheritance pattern. It also highlights the importance of appropriate family history taking when examining a TTM patient.
  1,430 23 -
EDITORIAL
Proceedings of the 7 th world congress of hair research
Patrick Yesudian
April-June 2013, 5(2):61-62
DOI:10.4103/0974-7753.122957  PMID:24403765
  1,324 40 -
LETTERS TO EDITOR
Mudichood: Well-known but rare entity
Gaurang Gupta, Priyanka Reshme, Kartik Raju, Vijetha Rai
April-June 2013, 5(2):101-101
DOI:10.4103/0974-7753.122974  PMID:24403777
  1,276 47 -
Trichothiodystrophy: Role of a dermato-trchologist
Fatemeh Livani, Naser Tayebi Meibodi, Omid Rajabi, Farah Ashrafzadeh, Pouran Layegh
April-June 2013, 5(2):102-103
DOI:10.4103/0974-7753.122975  PMID:24403778
  1,258 32 -
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