Year : 2011 | Volume
: 3 | Issue : 3 | Page : 8--9
Session B: Androgenetic Alopecia – Part II
|How to cite this article:|
. Session B: Androgenetic Alopecia – Part II.Int J Trichol 2011;3:8-9
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. Session B: Androgenetic Alopecia – Part II. Int J Trichol [serial online] 2011 [cited 2020 Feb 27 ];3:8-9
Available from: http://www.ijtrichology.com/text.asp?2011/3/3/8/82151
Androgen receptor gene polymorphism and skewed X chromosome inactivation in female androgenetic alopecia
Anastasia Mareeva*, Sergey Rotanov, Ilya Volkov
State Scientific-Research Centre for Dermatovenereology, Moscow, Russian Federation.
Genetic predisposition is considered to be the major requirement for the development of androgenetic alopecia (AGA). But it is little known about androgen receptor (AR) gene polymorphism and process of X inactivation in female AGA. The purpose of this study was to investigate whether skewed X chromosome inactivation (XCI) and the androgen receptor gene CAG repeat polymorphism are associated with AGA in Russian premenopausal women. AR gene was evaluated by using a polymerase chain reaction-restriction fragment length polymorphism in 87 AGA patients (29,5±5,4 years old) and 64 age-matched controls (29,3±5,7 years). The incidence of skewed XCI (>or=70%) was 50,7% in AGA group and 16,1% control group (P0<0,05). The median value is the same (21 CAG repeat) for both groups. The shorter (<22) CAG triplet repeat lengths in a combination of both alleles was more prevalent in AGA patients (P=0,0124; OR=0,25; 95%CI: 0,09-0,71). These data suggests that process of X inactivation and CAG-repeat length in AR gene are important for the development of AGA among Russian premenopausal women.
Investigation of variants of diverse hormone receptor genes in women with female pattern hair loss
Silke Redler 1 *, Rachid Tazi-Ahnini 2 , Pattie Birch 3 , Karen Dobson 3 , Felix F. Brockschmidt 1,4 , Dmitriy Drichel 5,6 , Kathrin A. Giehl 7 , Nadine Kluck 1,4 , Roland Kruse 8 , Gerhard Lutz 9 , Hans Wolff 7 , Tim Becker 5,6 , Markus M. Nöthen 1,4 , Andrew G. Messenger 3 , Regina C. Betz 1
1 Institute of Human Genetics, University of Bonn, Bonn, Germany, 2 Department of Infection and Immunity, University of Sheffield, Sheffield, U.K, 3 Department of Dermatology, Royal Hallamshire Hospital, Sheffield, U.K., 4 Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany, 5 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 6 Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany, 7 Department of Dermatology, University of Munich, Munich, Germany, 8 Dermatological Practice, Paderborn, Germany, 9 Hair and Nail, Wesseling, Germany.
Androgenetic alopecia (AGA) is a common hair loss disorder with a complex mode of inheritance, occurring in both men and women. In men, this condition is known as male-pattern hair loss, in women as female pattern hair loss (FPHL). Affected women typically present with a rather diffuse, mostly progressive thinning of hair at the crown. The etiopathogenesis of female pattern baldness is incompletely understood. Assuming that an androgen-independent pathway might play a role in the development of FPHL, we investigated 32 variants of several hormone receptor genes, including the aromatase-gene (CYP19A1), the progesterone receptor (PGR), the steroid-5-alpha-reductase alpha polypeptide 1 and 2 (SRD5A1, SRD5A2) and the estrogen receptors 1 and 2 (ESR1, ESR2). We used a sample of 145 unrelated white English and 53 German FPHL patients and 179 English, respectively 150 German controls. However, none of the genotyped variants showed any significant association in the overall samples, in subgroup analyses or meta-analyses, suggesting that CYP19A1, PGR, SRD5A1, SRD5A2, ESR1 and ESR2 are either not involved in the pathogenesis of AGA or the selected genetic variants have small effects that our study has not been able to detect. In future, further enlargement of the collective as well as a genome-wide association study might help to identify genes contributing to the development of FPHL.
The rs3185480 polymorphism of the adenomatosis polyposis coli down-regulated 1 (apcdd1) gene is associated with androgenic alopecia
Nikoletta Nagy 1,2 *, Ágnes Kinyó1 , Angéla Meszes 1 , Katalin Farkas 1 , Kinga Szentner 1 , Balázs Bende 1 , Réka Szabó1 , Lajos Kemény 1,2 , Márta Széll 2
1 Department of Dermatology and Allergology, University of Szeged, Szeged; 2 Dermatological Research Group of the Hungarian Academy of Sciences, Szeged, Hungary.
Adenomatosis polyposis coli down-regulated 1 (APCDD1) gene is an inhibitor of the Wnt signaling pathway therefore it may have a role in the development of the skin appendages. Moreover a mutation of this gene has been shown to be associated with a rare hair condition, hereditary hypotrichosis simplex. In this study, we aimed to investigate whether the single nucleotide polymorphisms (SNP) of APCDD1 gene contribute to the development of a common hair disease, androgenic alopecia. The genotypes of 9 SNPs in the coding region of the gene have been determined with direct sequencing. 210 patients with androgenic alopecia and 98 controls have been enrolled to the study. The severity of the androgenic alopecia was classified according to Hamilton-Norwood in the case of men and according to Ludwig in the case of women. We found a significant difference in the distribution of the genotypes of the c.1781C/T, p.L476L SNP (rs3185480) of the APCDD1 gene in exon 5, causing a 3.5 and a 2.8 times increased risk for the development of androgenic alopecia for the homozygote (CI 0.933 - 13.125; Nominal Regression P=0.063) and the heterozygote carriers (CI 1.086 - 7.217; Nominal Regression P=0.033) of the alleles respectively. Based on our results we conclude that carrying the c.1781C/T, p.L476L SNP (rs3185480) of the APCDD1 gene either in heterozygous or in homozygous form increases the risk for developing androgenic alopecia.
The impact of meditation in the treatment of androgenetic alopecia
Ademir Carvalho Leite Júnior 1 *, Fabiana Padovez 1,2
1 Clínica Dr Ademir Júnior and 2 Department of Hair Therapy of the Universidade Anhembi-Morumbi, São Paulo, Brazil.
Some studies prove that meditation brings many health benefits, but a few has been reported on the impact of meditation in patients with hair loss. 31 male volunteers between the age of 17 to 32 years were selected by our clinic to participate in a study involving meditation as part of the androgenic alopecia treatment. They were all diagnosed with androgenetic alopecia among levels III to IV on the Hamilton-Norwood scale. All patients received samples of 5% minoxidil hydroalcoholic lotion to be used topically twice a day. Only 16 of them received CDs with the mantra "Om"sound and were instructed to practice meditation 15 minutes twice a day according to a program suggested by a yoga teacher. Patients were evaluated by TrichoScan software before the treatment starts and 6 months later. After 6 months follow-up and 3 cases of abandonment in the meditation group and 2 cases of abandonment in the group who has not practiced meditation, the results showed a small but significant and positive difference in their hair loss. The results were confirmed by TrichoScanon the patients who practiced meditation. Those who did meditation reported greater willingness and balance in everyday tasks in addition to the hair loss reduction, as well as an improvement in hair appearance. Our conclusion is that meditation was important for patients to reduce their stress levels and, consequently, to achieve better results in their androgenetic alopecia treatments.