Year : 2011 | Volume
: 3 | Issue : 3 | Page : 30-
Session O: The Hair Follicle – Part II
|How to cite this article:|
. Session O: The Hair Follicle – Part II.Int J Trichol 2011;3:30-30
|How to cite this URL:|
. Session O: The Hair Follicle – Part II. Int J Trichol [serial online] 2011 [cited 2020 Feb 20 ];3:30-30
Available from: http://www.ijtrichology.com/text.asp?2011/3/3/30/82164
Mesenchymal control of hair follicle formation
Carlos Clavel1,2, Laura Grisanti 1,2 , Su-Yi Tsai 1,2 , Michael Rendl 1,2,3, *
1 Black Family Stem Cell Institute, 2 Department of Developmental and Regenerative Biology, 3 Department of Dermatology, Mount Sinai School of Medicine, New York, USA.
Stem cell activation orchestrated by signals from dermal papilla (DP) cells in the stem cell niche is essential for hair follicle morphogenesis and for hair regeneration during the cycle. The nature of these signals and how they are regulated remains elusive, mostly due to the lack of genetic tools for isolating and targeting the DP compartment. We have recently developed transgenic mice to isolate DP cells and defined their molecular signature. Here, we report a novel gene targeting system that allows knocking out genes specifically in DP precursors at the earliest stages of hair formation, and more widespread in the mesenchyme at later stages. We then use this system to ablate DP signature genes and demonstrate their role in follicle formation and regeneration during morphogenesis and the cycle, respectively.