International Journal of Trichology International Journal of Trichology
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REVIEW ARTICLE
Year : 2009  |  Volume : 1  |  Issue : 1  |  Page : 15-17

Hair abnormalities in genetic disorders of junctions


Glan Clwyd Hospital, Denbigshire, United Kingdom

Correspondence Address:
Paul D Yesudian
Department of Dermatology, Glan Clwyd Hospital, Denbigshire, North Wales LL18 5UJ.
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-7753.51926

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The desmosomes form the basis of intercellular support structure within the epidermis. However, various junctions, including gap junctions, adherens junctions, and tight junctions play an important part in the intercellular bridges that are vital for cell-cell interactions and structural stability. Numerous mutations can affect the genetic structure that make up these junctions and in turn cause disease. Most of these conditions have hair abnormalities and this article will briefly elucidate the various manifestations in the hair. As these junctional elements are found in other organs like the heart, liver, and eye, there could be serious systemic associations along with the hair changes.


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